Discovery of FVIII “Aurora” Mutation Opens New Perspectives for Hemophilia A Therapy.
Naturally occurring gain-of-function variant shows enhanced activity and reduced sensitivity to activated protein C.
TribeMD
3 min read
August 14, 2025
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Pediatrics
Sources
- Wischmeyer JT, Baird CH, Grandvallet Contreras J, et al. A Naturally Occurring Gain-of-Function Mutation in Factor VIII. N Engl J Med. 2025;393(7):722-724. doi:10.1056/NEJMc2507228.
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